ABSTRACT
AIM:To investigate the changes of retinal microcirculation after phacoemulsification and the influencing factors of visual acuity.METHODS: Retrospective analysis. A total of 264 cataract patients(264 eyes)who underwent phacoemulsification in our hospital from January 2022 to December 2022 were selected as the study objects. Patients were divided into < 0.3 group(66 eyes)and ≥0.3 group(198 eyes)according to the recovery of best corrected visual acuity(BCVA)at 3 mo after surgery. The changes of retinal microcirculation indexes were compared before and after treatment. Logistic regression and LASSO regression models were used to screen the influencing factors of postoperative BCVA. A nomogram prediction model of postoperative BCVA was constructed and verified. A restricted cubic spline Logistic regression model was established to analyze the dose-response relationship between end-diastolic velocity(EDV), peak systolic velocity(PSV)and the risk of BCVA recovery.RESULTS: At 3 mo postoperatively, EDV and PSV were significantly improved compared with those before treatment, and resistance index(RI)levels were significantly lower than those before treatment(all P<0.05). Preoperative EDV, PSV, aqueous humor cell grade, fundus lesion grade, advanced age and Emery grade were influencing factors for poor BCVA recovery after phacoemulsification in cataract patients(P<0.05). The AUC before and after validation of the nomogram model by Bootstrap method were 0.869(95%CI: 0.815-0.903)and 0.866(95%CI: 0.802-0.895), respectively. The sensitivity was 88.36% and 88.27%, and the specificity was 91.82% and 91.78%, respectively. Restricted cubic spline model analysis showed no nonlinear dose-response relationship between EDV and PSV levels and the risk of poor BCVA recovery in either male or female(P>0.05).CONCLUSION: After phacoemulsification, retinal microcirculation in cataract patients improved significantly. EDV, PSV, aqueous humor cell grade, fundus lesion grade, advanced age and Emery grade are all factors influencing poor BCVA recovery after cataract surgery.
ABSTRACT
Objective: To investigate effect of femtosecond laser-assisted phacoemulsification in treating cataract patients, and to analyse its influence on serum inflammatory factors IL-6, IL-1beta, TNF-alpha
Study Design: An analytical, descriptive study
Place and Duration Of Study: The Ophthalmologic Center, Rehabilitation Center Hospital of Gansu, China, from January 2016 to September 2017
Methodology: A total of 94 eyes were randomly divided into control group [47 cases] and observation group [47 cases]. Control group was treated with traditional phacoemulsification. The observation group was added with femtosecond laser based on the treatment of the control group. Clinical efficacy of two groups was compared
Results: Surgery time of the observation group was longer than that of the control group [p<0.001]. Effective phacoemulsification time, cumulative dissipated energy, and liquid flow of the observation group were all less than those of the control group [all p<0.001]. One day after surgery, aqueous flare and rate of corneal endothelium loss in the observation group were less than those of the control group [both p<0.001]. Seven days after surgery, serum levels of IL-6, IL-1beta and TNF-alpha in the observation group were lower than those of the control group [all p<0.001]
Conclusion: Femtosecond laser-assisted phacoemulsification has better clinical effect in treating cataract, and can reduce the energy and time cost in the phacoemulsification, decrease the serum levels of inflammatory factors and cause less postoperative complications. But it takes longer operation time and relatively higher treatment cost